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Therefore, we performed the STM test 3–4 h after conditioning and the LTM test 24 h after conditioning, similar to our previous studies (Nader et al.This pattern of findings, intact STM and impaired LTM, suggests that de novo m RNA synthesis in the lateral amygdala is required for the consolidation of auditory fear memories.Memory formation is a time-dependent process by which an initially labile memory is consolidated into stable long-term memory (LTM) via de novo RNA and protein synthesis (Davis and Squire 1984; Dudai and Morris 2000; Mc Gaugh 2000; Kandel 2001).
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One key question is whether protein synthesis during reconsolidation depends on already existing m RNAs or on synthesis of new m RNAs in the amygdala.